RG11: Reno-Vascular Diseases
The multidisciplinary RG11 includes nephrologists, cardiologists and internists, from hospitals associated with NOVA Medical School, and also pharmacologists and biochemists, focused in the kidney and its role in the pathogenesis of TL2: Cardio-Metabolic Disorders, aiming to improve diagnosis and treatment options (haemodialysis, peritoneal dialysis, transplantation, drugs).
- Reducing cardiovascular mortality in haemodialysis and kidney transplanted patients with particular emphasis in manipulation of the Ca++ PO4-- Mg++ buffer system and decreasing vascular calcifications (Nolasco, Ferreira, Adragão);
- Reducing arterial hypertension, targeting the changes in renal sympathetic nervous system and the deleterious effect of ischemia-reperfusion cycles in the kidney, characteristic of sleep apnoea or chronic intermittent hypoxia conditions (Monteiro, Almeida, Branco, Gonçalves);
- Identifying new molecular biomarkers of tubular damage and repair common to several comorbidities, eg. HIV infection, xenobiotic and diabetes (Pereira, Soto)
- Improving the results of peritoneal dialysis, analysing histomorphological features of peritoneal biopsies and metabolomics of the effluent (Branco, Cabral, Fontao)
- Using metabolomics to improve the diagnosis and treatment of antibody mediated rejection in renal transplantation (Viana, Nolasco, Aires, Ramalhete, Calado, Trindade)
- Diagnosis and treatment of Hemolytic Uremic Syndrome, using Eculizumab specifically in transplantation of patients with HUS (Calado, Nolasco, Viana)
Other interests: therapeutic (drug and device) interventions, eg. effects of cholecalciferol and magnesium phosphate binder in reducing vascular calcifications; chronic consequences of ablation of renal sympathetic nervous system; pharmacological manipulation of hypertension secondary to sleep apnea, prospective follow up on diabetic nephropathy.
Keywords: Vessel calcification; Peritoneal dialysis; Kidney transplantation; Chronic intermittent hypoxia
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